In biomanufacturing, downstream processing is often the bottleneck—particularly filtration steps like concentration, washing (diafiltration), and polishing. Every delay, manual intervention, or failed batch increases costs, wastes resources, and slows time-to-market. The ePROD® TFF system, featured by CoPure, is engineered to break that bottleneck.
An advanced, fully automated Tangential Flow Filtration (TFF) platform with up to 65 m² of filtration surface, this system brings automation, flexibility, and control to industrial-scale filtration—empowering teams to meet GMP compliance and focus on science, not system churning.
Why advanced TFF matters (data + business case)
Productivity gains: Manual TFF systems often require constant oversight—sampling, pressure adjustment, and cleaning between steps. Automation cuts that idle operator time, letting technologists scale more runs per day.
Consistency and scalability: Tuning TMP (transmembrane pressure) and flow manually across large surface areas invites variability; an automated, sensor-driven system ensures each run follows the same profile, facilitating reproducible scale-up.
Reduced downtime, faster CIP cycles, less preventive maintenance—all lead to lower cost per gram of product and greater facility throughput.
ePROD® TFF at a glance
Filtration surface: 7–65 m², configurable with cassette, ceramic, or hollow-fibre modules
Core components: Magnetic-agitated feed vessel; two industrial-grade pumps: one for recirculation, one for in-situ cleaning
Operations: Supports concentration, diafiltration, TMP control, and CIP modes with precision automation
Control panel: User-friendly interface with multi-user logins, real-time digital sensor data, and recipe management (fully GMP-compatible)
Materials: 316L stainless steel, corrosion-resistant, built for long-term integrity
Design: Fully automated—minimising human error, facilitating continuous operations, and improving equipment longevity
Validation ready: Meets GMP standards and simplifies documentation for regulated biomanufacturing
Deep-dive: Key features and technical advantages
Large, adaptable surface area
With up to 65 m² of membrane area, the ePROD TFF system handles large batch volumes—from 50 L to several thousand liters—using appropriate recirculation strategies. The choice of cassette, ceramic, or hollow-fiber modules allows users to match particle size, fouling profile, and throughput needs to their bioprocess.
Dual-pump architecture for efficiency and CIP
The system employs:
A product recirculation pump, optimised for shear-friendly flow dynamics.
A centrifugal pump dedicated to in-situ cleaning, eliminating the need for external CIP circuits.
This design means cleaning cycles are faster, easier, and reduce downtime—critical for maximising throughput in industrial operations.
Precision modes: concentration, diafiltration, TMP control, CIP
Each mode is automated:
Concentration: Removes solvent while maintaining product quality.
Diafiltration: Exchanges buffers or removes impurities by adding a clean buffer as filtrate exits.
TMP regulation: System automatically adjusts pressure and flow to maintain a target transmembrane pressure—protecting filters from fouling or over-stress.
CIP: Steams, washes, or chemically cleans without manual reconfiguration, preserving operational hygiene.
Automated control, GMP ready
Multi-user access and recipe management ensure controlled access and traceability.
Sensor suite and UI monitor flow rates, pressure, temperature, and conductivity—enabling documentation, deviation alerts, and data capture for QA/QC.
The GMP-aware architecture supports electronic batch records, validation protocols, and audit readiness.
Durable build with 316L stainless steel
316L SS is widely used in the biopharma industry for its chemical resistance and cleanability—ensuring ePROD’s longevity, low maintenance, and compatibility with aggressive cleaning agents.
Use-cases where ePROD® TFF drives measurable impact
| Application |
Value Delivered |
| Monoclonal antibodies (mAb) concentration & diafiltration |
Removes buffer and concentrates product quickly, at volume, with consistent recovery rates. |
| Viral vector clarification |
Handles shear-sensitive products with TMP control to avoid structural damage. |
| Nanofiltration for small molecules |
Works with ultrafiltration membranes for separation of small molecules or high-value peptides. |
| Vaccine downstream processing |
Automates CIP and TMP control to ensure rapid production runs with reduced cross-contamination risk. |
Operational best practices
Design pore/module to process flux: High surface area needs a correct pore size to avoid slow flux or dead zones.
Monitor TMP and flow patterns: Early detection of increases in TMP during concentration signals fouling—system auto-adjusts, but logs provide research insight.
Validate CIP routines: Use the in-situ pump for chemical and steam cycles; verify conductivity return to baseline post-cleaning.
Document sensor trends vs batch outcomes: Correlate pressure drops, flow shifts, or temp spikes with assay results for process optimisation.
Final word: Future-ready downstream filtration
The ePROD® TFF system combines scale, automation, and compliance in a single industrial-grade TFF platform. Whether your team is:
Scaling mAbs from pilot to production,
Establishing viral vector processing workflows,
Or optimising peptide purification—
This system is built to support them with reliable, traceable, and high-throughput filtration.
For Further Enquiry Contact- sales@copure.com.au
