As the demand for high-performance depth filters in Australia continues to grow—particularly across plasma fractionation, biologics, vaccine processing, and high-purity pharmaceutical manufacturing—laboratories are shifting toward filtration technologies that provide consistency, purity, and strong contaminant retention.

The Roheap CSD Depth Filter Sheet series from Cobetter, available through CoPure, is engineered specifically for applications where strict purity levels and strong mechanical strength are non-negotiable. Leveraging advanced material science and stringent batch-to-batch QC controls, these filter sheets are designed to deliver reliable clarification even under demanding operating conditions.

This makes the Roheap CSD DEBL50 and Roheap CSD CEBLS4 depth filter sheets ideal choices for Australian laboratories seeking precise, compliant and efficient filtration solutions.

Designed for High-Purity Clarification

The performance advantages of the Roheap CSD series stem from its unique construction:

Roheap CSD DEBL50 Depth Filter Sheet (with filter aids)

Composed of:

• High-purity cellulose fibres

• Synthetic resin for strength and charge effects

• Inorganic filter aids, enhancing retention and adsorption
  

The three-dimensional internal matrix provides strong depth filtration capability, capturing a wide range of particle sizes across multiple layers.

Roheap CSD CEBLS4 Depth Filter Sheet (no filter aids)

Built with:

• High-purity cellulose

• Synthetic resin

With no diatomaceous earth or inorganic aids, this sheet is ideal when minimising ash, metal ions, or extractable content is critical. It delivers a smooth filtration surface and is suited for processes sensitive to inorganic residues.

Both variants undergo rigorous validation to ensure:

• Extremely low extractables

• Very low metal leachables

• Endotoxin levels < 0.25 EU/mL

• Biocompatibility in accordance with USP <87>

• Biological reactivity compliance per USP <88> Class VI

For labs operating under strict GMP or TGA-regulated environments, these parameters help strengthen compliance and process reliability.

Uniformity Through Advanced Manufacturing

Cobetter’s globally recognised production capability is built on highly automated manufacturing lines and strict raw-material screening. This ensures:

• Consistent sheet thickness

• Controlled porosity

• Stable retention characteristics

• Predictable wet strength and hydraulic performance

For lab managers relying on reproducible results, this manufacturing precision is crucial—especially when scaling from pilot-scale to full production.

Technical Specifications and Performance Insights

The Roheap CSD series provides strong mechanical and hydraulic characteristics suited for demanding clarification tasks.

Core Specifications

Operational Limits

Max operating temperature: 80°C

Max differential pressure:

0.3 MPa at 40°C

0.24 MPa at 80°C

These parameters ensure the sheets can support extended filtration cycles without compromising structural integrity or releasing particulates.

Chemical Compatibility

The Roheap CSD filter sheets offer broad compatibility with acids, alcohols and industrial solvents—critical for plasma processing, buffer preparation and CIP environments.

They exhibit good (G) compatibility with:

• NaOH (2% at 20°C)

• HCl, HNO₃, H₂SO₄ (at 20°C)

• Acetic acid (38%)

• Citric acid (10%)

• Peracetic acid (0.1%)

• Butanol (80%)

• Ethanol (80%)

At elevated temperatures (80°C), performance remains strong with many of these chemicals, reflecting robust structural durability.

Designed for Pharmaceutical and Plasma Applications

The Roheap CSD sheets are well aligned with Australia’s fast-growing biologics and plasma industry. Their high-purity design supports multiple applications:

Primary Use Cases

1. Plasma and Plasma Fractionation

• Effective removal of lipids, cell fragments, precipitates

• Consistent retention of impurities during Cohn fractionation

• Low endotoxin contribution, protecting downstream processes
  

2. Clarification Filtration

Suitable for:

• Bioreactor cell culture

• Fermentation broths

• Enzyme formulations

• Vaccines and biologic intermediates
  

Their structural depth enables strong retention without premature clogging.

3. Applications Requiring Low Ash or Low Metal Content

The CEBLS4 variant (ash <1%) is ideal for:

• High-purity reagent manufacturing

• Diagnostics

• Sensitive protein processing workflows
  

4. Filtration Cake Recovery

The hydrophobic surface and smooth sheet make cake removal easier, supporting product recovery and post-filter analysis.

Why These Depth Filters Matter for Australian Laboratories

With the rise of biologics, blood products, high-purity chemical research and advanced therapeutics, laboratories in Australia increasingly require depth filtration media that meet:

• Global regulatory standards

• High mechanical strength

• Low extractables

• Reliable and consistent performance

• Strong contaminant retention

The Roheap CSD series addresses all these requirements while offering scalable, high-purity filtration suited for both pilot-scale and production workflows.

As more facilities modernise their clarification systems, high-grade depth filters in Australia like Roheap CSD are becoming essential to maintaining product quality, reproducibility and regulatory compliance.

For Further Enquiry Contact- sales@copure.com.au